Journal: Cancers

Article Title: High G9a Expression in DLBCL and Its Inhibition by Niclosamide to Induce Autophagy as a Therapeutic Approach.

doi: 10.3390/cancers15164150

Figure Lengend Snippet: Figure 1. The gene expression profiling interactive analysis through the GEPIA software. DL- BCL data were analyzed in TCGA and GTEx databases through the GEPIA web-based software, showing that G9a was more highly expressed in DLBCL tumor tissues than in normal tissues. Abbreviations: The Cancer Genome Atlas (TCGA), the Genotype-Tissue Expression (GTEx), adreno- cortical carcinoma (ACC), bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), cholangiocarcinoma (CHOL), colon adenocarcinoma (COAD), lymphoid neoplasm diffuse large B-cell lymphoma (DLBC), esophageal carcinoma (ESCA), glioblastoma multiforme (GBM), head and neck squamous cell car- cinoma (HNSC), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), acute myeloid leukemia (LAML), brain lower grade glioma (LGG), liver hepatocellular carcinoma (LIHC), Lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), mesothelioma (MESO), ovarian serous cystadenocarcinoma (OV), pancreatic adenocarcinoma (PAAD), pheochromocytoma and paraganglioma (PCPG), prostate adenocarcinoma (PRAD), rectum adenocarcinoma (READ), sarcoma (SARC), skin cutaneous melanoma (SKCM), stomach adenocarcinoma (STAD), testicular germ cell tumors (TGCT), thyroid carcinoma (THCA), thymoma (THYM), uterine corpus endometrial carcinoma (UCEC), uterine carcinosarcoma (UCS), uveal melanoma (UVM) (*, p < 0.05).

Article Snippet: Human DLBCL cell lines (U2932, HT, SU-DHL-5, and RC-K8) were purchased from the American Type Culture Collection (ATCC, Rockville, MD, USA) and the Bioresource Collection and Research Center (BCRC, Hsinchu, Taiwan).

Techniques: Gene Expression, Software, Expressing

Journal: Journal of clinical medicine

Article Title: Phenotypic Characterization of Diffuse Large B-Cell Lymphoma Cells and Prognostic Impact.

doi: 10.3390/jcm8071074

Figure Lengend Snippet: Figure 2. CD39 expression discriminates between GCB and ABC DLBCL primary tumors and cell lines. Cluster gram showing the expression of MME, BCL6, ENTPD1, and BCL2 genes in ABC DLBCL samples (n = 167) and GCB DLBCL samples (n = 183) in the ABC and GCB DLBCL samples from the R-CHOP and CHOP Lenz cohorts (gene expression profile, GEP, data) (a). (B) Boxplots illustrate the expression signal (GEP) of ENPD1 in ABC DLBCL samples and in GCB DLBCL samples in the Lenz cohort (b). Boxplots showing CD39 mean fluorescence intensity (MFI, logarithmic scale) in 16 DLBCL derived-cell lines (c). The boxes indicate the 25th and 75th percentile values. The line in the middle corresponds to the median. The vertical lines, to the 10th and the 90th percentiles. The outliers are identified as the third quartile plus 1.5 IQR (interquartile range); * p-value < 0.05 (Mann-Whitney U-test). GCB: germinal center B cell–like, ABC: Activated B cell–like, DLBCL: diffuse large B cell lymphoma.

Article Snippet: The 16 DLBCL cell lines (DOHH2, HT, OCI-LY19, DB, OCI-LY1, SUDHL-4, SUDHL-5, SUDHL-10, NUDHL-1, OCI-LY7, WSU-DLCL2, SUDHL-6, NUDUL-1, U2932, OCI-LY3, and RI-1) were purchased from the American Type Culture Collection or from DSMZ (Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Germany).

Techniques: Expressing, Gene Expression, Derivative Assay, MANN-WHITNEY

Journal: Journal of clinical medicine

Article Title: Phenotypic Characterization of Diffuse Large B-Cell Lymphoma Cells and Prognostic Impact.

doi: 10.3390/jcm8071074

Figure Lengend Snippet: Figure 6. BCL6 expression correlates with the response to etoposide in DLBCL cell lines. Box-plots illustrate the inhibitory concentration 50 (IC50) of etoposide on a logarithmic scale. The boxes represent the 25th and 75th percentile values. The line in the middle corresponds to the median. The vertical lines correspond to the 10th and the 90th percentiles, and the circles, to the outliers. * p value < 0.05 (Mann-Whitney U-test) (a). Linear regression analysis of BCL6 expression (MFI) in function of the IC50 of etoposide in 16 DLBCL cell lines. r represents the Spearman correlation coefficient, p value <0.05 (Spearman correlation test) (b).

Article Snippet: The 16 DLBCL cell lines (DOHH2, HT, OCI-LY19, DB, OCI-LY1, SUDHL-4, SUDHL-5, SUDHL-10, NUDHL-1, OCI-LY7, WSU-DLCL2, SUDHL-6, NUDUL-1, U2932, OCI-LY3, and RI-1) were purchased from the American Type Culture Collection or from DSMZ (Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Germany).

Techniques: Expressing, Concentration Assay, MANN-WHITNEY